Search results for " exhaled nitric oxide"

showing 3 items of 3 documents

Asthma control in severe asthmatics under treatment with omalizumab: A cross-sectional observational study in Italy

2015

Few data are available on the proportion of asthmatics achieving a good asthma control (according GINA guidelines) and on the level of airway inflammation during omalizumab treatment. The aim of this cross-sectional national observational study was to assess the level of control (according to GINA guidelines) achieved in a group of asthmatics on omalizumab treatment, and to characterize the factors that influence the lack of control. We studied 306 asthmatics under omalizumab treatment for a median of 32 months (range 4-120). The level of control according to GINA was good in 25.2%, partial in 47.1% and poor in 24.5% of patients (data were missing for the remaining 3.2%). Comparison between…

AdultMalePulmonary and Respiratory Medicinemedicine.medical_specialtyExacerbationCross-sectional studyOmalizumabOmalizumabComorbiditySettore MED/10 - Malattie Dell'Apparato RespiratorioExhaled nitric oxide; Exacerbations; Comorbidities; Asthma; Omalizumab; ControlSeverity of Illness IndexComorbiditiesExacerbationsExhaled nitric oxideInternal medicineSeverity of illnessControlMedicineAnti-Asthmatic AgentHumansPharmacology (medical)Anti-Asthmatic AgentsInflammation MediatorAsthmaRespiratory Function TestAgedCross-Sectional Studiebusiness.industryBiochemistry (medical)ExacerbationMiddle Agedmedicine.diseaseComorbidityAsthmaRespiratory Function TestsCross-Sectional StudiesItalyExhaled nitric oxidePhysical therapyObservational studyAsthma; Comorbidities; Control; Exacerbations; Exhaled nitric oxide; Omalizumab; Adult; Aged; Anti-Asthmatic Agents; Asthma; Comorbidity; Cross-Sectional Studies; Female; Humans; Inflammation Mediators; Italy; Male; Middle Aged; Omalizumab; Respiratory Function Tests; Severity of Illness Index; Pulmonary and Respiratory Medicine; Biochemistry (medical); Pharmacology (medical)FemaleComorbiditieInflammation Mediatorsbusinessmedicine.drugHuman
researchProduct

Repeatability of exhaled breath fingerprint collected by a modern sampling system in asthmatic and healthy children

2019

E-noses provide potential non-invasive metabolic biomarkers for diagnosing and monitoring pulmonary diseases. The primary aim of the present study was to assess the within-day and between-day repeatability of a modern breath sampling system (Pneumopipe® plus an array of e-nose sensors) in asthmatic and healthy children. The secondary aim was to compare the repeatability of the breath sampling system, spirometry and exhaled nitric oxide (eNO). Fifteen children (age 6-11 years) with asthma and thirty healthy children matched by age and gender (1:2 allocation) were recruited; of them, three healthy children did not complete the study. All measurements were collected twice during the baseline v…

MalePulmonary and Respiratory MedicineSpirometrymedicine.medical_specialtyspirometryRegistration systemNitric Oxide01 natural sciences03 medical and health sciences0302 clinical medicinechildrenInternal medicineStatistical significanceasthma children e-nose exhaled nitric oxide repeatability spirometrymedicineHumanse-noserepeatabilityChildAsthmamedicine.diagnostic_testbusiness.industry010401 analytical chemistryReproducibility of ResultsRepeatabilityasthmamedicine.disease0104 chemical sciencesSampling systemAsthmatic childrenBreath Tests030228 respiratory systemExhalationCase-Control StudiesExhaled nitric oxideexhaled nitric oxideFemaleFactor Analysis StatisticalbusinessJournal of Breath Research
researchProduct

Resolvin D1 and miR‐146a are independent distinctive parameters in children with moderate and severe asthma

2020

To date, a large number of mediators and biomarkers have been detected in childhood asthma, with a potential role in monitoring the disease course. Lung function evaluation through spirometry, forced oscillation technique and multiple breath washout proved its role in asthma monitoring, especially for investigating small airway impairment in children with more severe symptoms. Recently, novel specialized pro-resolving mediators, such as resolvins and lipoxins, have been recognized as crucial in promoting the resolution of lung inflammation. Increasing evidence suggests that miRNAs are crucially entailed in asthma. Partial least squares discriminant analysis (plsDA) is a modern technique for…

Malemedicine.medical_specialtyDocosahexaenoic AcidsNeutrophilsSevere asthmaVital CapacityImmunologySeverity of Illness IndexLeukocyte CountSettore MED/38 - Pediatria Generale E SpecialisticachildrenForced Expiratory VolumeInternal medicineHumansImmunology and AllergyMedicineLeast-Squares AnalysisChildAsthmabusiness.industryDiscriminant Analysisasthmamedicine.diseaseResolvin d1EosinophilsmiR-146aMicroRNAsFractional Exhaled Nitric Oxide Testingpartial least squares discriminant analysisresolvin D1FemalebusinessClinical & Experimental Allergy
researchProduct